Analytical interference in plasma iron determination reveals gadolinium vs. iron transmetallation with linear gadolinium chelates
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Analytical Interference in Serum Iron Determination Reveals Iron Versus Gadolinium Transmetallation With Linear Gadolinium-Based Contrast Agents
OBJECTIVES The purposes of this study were to evaluate the risk for analytical interference with gadolinium-based contrast agents (GBCAs) for the colorimetric measurement of serum iron (Fe³⁺) and to investigate the mechanisms involved. MATERIALS AND METHODS Rat serum was spiked with several concentrations of all molecular categories of GBCAs, ligands, or "free" soluble gadolinium (Gd³⁺). Seru...
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Extracellular gadolinium contrast agents (Gd-CA) are either linear or macrocyclic chelates available as ionic or non-ionic preparations. The molecular structure whether cyclic or linear and ionicity determines the stability of Gd-CA. Linear chelates are flexible open chains which do not offer a strong binding to Gd(3+). In contrast, the macrocyclic chelates offer a strong binding to Gd(3+) by t...
متن کاملAnalytical Interference by Contrast Agents in Biochemical Assays
Objective To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spike...
متن کاملDual Contrast Method for Cellular MRI using Positive and Negative Contrast Agents
Introduction: MR contrast agents (CAs) are important elements for cellular MRI. Gadolinium (Gd) chelates are used in T1-weighted production of positive signal contrast while superparamagnetic iron oxide particles (SPIOs) produce T2-weighted signal reduction. Although SPIOs provide more sensitivity toward cell labeling compared to Gd-chelates, the negative contrast generated by the SPIOs may be ...
متن کاملUltrastructural evidence of dermal gadolinium deposits in a patient with nephrogenic systemic fibrosis and end-stage renal disease.
BACKGROUND AND OBJECTIVES The pathogenesis of acquired nephrogenic systemic fibrosis recently described for patients with renal insufficiency and a history of exposition to gadolinium-based magnetic resonance contrast agents is not completely understood. A role for circulating fibroblasts in the fibrosing tissue is hypothetical, and the mechanism of the assumed trigger function of gadolinium re...
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